A meta-analysis of medicinal plants to assess the evidence for toxicity
نویسندگان
چکیده
Toxicity of phytochemicals, plant-based extracts and dietary supplements, and medicinal plants in general, is of medical importance and must be considered in phytotherapy and other plant uses. We show in this report how general database analyses can provide a quantitative assessment of research and evidence related to toxicity of medicinal plants or specific phytochemicals. As examples, several medicinal plants are analyzed for their relation to nephrotoxicity and hepatotoxicity. The results of analyses in different databases are similar, and reveal the two best-established toxic effects among the group of plants that were examined: nephrotoxicity of Aristolochia fangchi and hepatotoxicity of Larrea tridentata.
منابع مشابه
Morphine withdrawal attenuating effect, toxicity and alkaloid composition of Sophora alopecuroides L. var. alopecuroides
Background and objectives: The seedsof Sophora alopecuroides L. var. alopecuroides may benefit treatment of opioid dependence. Therefore, the plant alkaloid composition, toxicity and effects on morphine withdrawal were studied. Methods: The alkaloid composition was determined by GC and GC/MS analysis. Mice were made dependent by morphine injec...
متن کاملThe methodology of research in Traditional Medicine
In countries having traditional medicine (TM), one of the main challenges for any researcher is research methodology. Current methodologies are different with what was in past. The main purpose of this article is to present the steps (herbs, claims and methodology) of research in TM fields. 1. Assessment of herbs History, method of study, quality assessment, efficacy, safety, toxicity and the...
متن کاملThe methodology of research in Traditional Medicine
In countries having traditional medicine (TM), one of the main challenges for any researcher is research methodology. Current methodologies are different with what was in past. The main purpose of this article is to present the steps (herbs, claims and methodology) of research in TM fields. 1. Assessment of herbs History, method of study, quality assessment, efficacy, safety, toxicity and the...
متن کاملScreening seven Iranian medicinal plants for protective effects against β-Amyloid-induced cytotoxicity in cultured cerebellar granule neurons
Background and objectives: Alzheimer's disease (AD) as a neurodegenerative disorder is the most common form of dementia in the elderly. According to the amyloid hypothesis, accumulation of amyloid beta (Aβ) plaques, which are mostly constituted of Aβ peptide aggregates, triggers pathological cascades that lead to neuronal cell death. Thus, modulation of Aβ toxicity is the hopef...
متن کاملEffect of ginger supplement on lipid peroxidation induced by exercise- A meta-analysis study
Background: There are often discrepancies in the results of various studies in the field of exercise and herbal supplements. Objective: The aim of this study was to combine the contradictory results of several studies on the effectiveness of ginger supplement on lipid peroxidation in exercise. Methods: This meta-analysis consists of a total of 3 eligible studies selected from among the 6 studie...
متن کامل